The paper examines the influence of spiritual potential on the secular context of the history of particular chronologic continuum via patron saints. At a certain stage in the history of both Russian and Czech people St. Sergius and St. Ludmila became symbols of uplift. A comparative analysis of two different hagiografical corps devoted to Sergius of Radonezh and Saint Ludmila is provided. On the basis of these sources the author has drawn some conclusions serving as a basis for the comparative analysis of the saints in the context of the history of Christianity in the Eastern Europe. Some aspects of the history of canonization and veneration of saints both in Russia and the Czech Republic are touched upon. Great importance in the history and culture of both nations is attached to the role of spiritual centers associated with Sergius of Radonezh and Saint Ludmila they are the Trinity Lavra of St. Sergius in Russia and the Convent of St. George in the Czech Republic.